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A total of 3 % of Lively material is excreted in urine as unchanged active material. Tapentadol is Furthermore metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 also to hydroxy tapentadol (two %) by CYP2D6, which happen to be additional metabolised by conjugation. Consequently, active material metabolism mediated by cytochrome P450